Monday, September 16, 2024
Program subject to change.
8:30 am - 9:30 am | Plenary Lecture 1
Endogenous Biomarker-informed Approaches for Evaluation of Transporter-mediated Drug-drug and Drug-disease Interactions
Aleksandra Galetin, University of Manchester, Manchester, United Kingdom
9:30 am - 10:00 am | Refreshment Break with Posters and Exhibitors
9:45 am - 10:00 am | WuXi AppTec Thought Leadership Presentation: In vitro DDI Consideration for Developing New Modalities
Dr. Libo Xu, Sr. Director of ADME, WuXi AppTec
10:00 am - 12:00 pm | Concurrent Symposia 1 and 2
Symposium 1: DDI - From Research to Regulatory to Clinical
Co-Chairs: Akihiro Ishiguro, PMDA, Tokyo, Japan and Xinning Yang, Ellicott City, Maryland, USA
Review of Finalized ICH M12 Guideline on Drug Interaction Studies
Akihiro Ishiguro, PMDA, Toyko, Japan
Novel Preclinical Approaches for DDI Risk Assessment in Drug Discovery and Development
Niresh Hariparsad, AstraZeneca, Waltham, Massachusetts, USA
Strategies for Clinical Interpretation of Complex Drug-Drug Interactions
Manoli Vourvahis, Pfizer, New York, New York, USA
Utilizing PBPK Modeling and in vitro Data for Predicting Complex DDIs of OATP1B, P-glycoprotein and CYP Substrates Caused by Various Perpetrators
Yuichi Sugiyama, Josai International University, Tokyo, Japan
Utility of Mechanistic Static Models for Predicting CYP- and Transporter-Mediated DDI
Sheila Peters, Boehringer-Ingelheim, Mainz, Germany
Symposium 2: Beyond Small Molecule Modalities
Co-Chairs: Kenta Haraya, Chugai Pharmaceutical, Singapore and Anshul Gupta, Generation Bio, Cambridge, Massachusetts, USA
Targeted Protein Degraders (TPD): PK/PD Translation from Preclinical to Clinical
Dapeng Chen, Kymera Therapeutics, Watertown, Massachusetts, USA
Improving ADME Properties of Therapeutic Antibodies by Novel Engineering Technologies
Kenta Haraya, Chugai Pharmaceutical, Yokohama, Japan
Defining the Therapeutic Window of Bi-specific T-cell Engagers
Kip Conner, Amgen, South San Francisco, California, USA
Assessment of ADME and DDI for LNP-mRNA Therapeutics
Lei Ci, Moderna Therapeutics, Cambridge, Massachusetts, USA
12:00 pm - 3:00 pm | Exhibits, Poster Presentations, and Thought Leadership Presentations
12:00 pm - 1:00 pm: Lunch on Own, Exhibit Hall Hours, and Poster Viewing
12:00 pm - 12:45 pm: A1- A6 Poster Award Finalist Presentations
12:45 pm - 1:30 pm: A7 - A12 Poster Award Finalist Presentations
1:30 pm - 3:00 pm: Poster Presentation Session 1 - P1 - P99 and P339 - P340
1:30 pm - 2:15 pm: Odd-Numbered Posters
2:15 pm - 3:00 pm: Even-Numbered Posters
1:45 pm - 2:00 pm | WuXi AppTec Thought Leadership Presentation: Smart Ideas of ADME-PK for Large Molecules - Insights and Solutions for ADCs and Oligos
Lijuan Hou, Director of WuXi AppTec DMPK
2:30 pm - 2:45 pm | BioIVT Thought Leadership Presentation: In vitro ADME Inside Out: Sharing the Console
Joanna Barbara, Ph.D., BioIVT
3:00 pm - 5:00 pm | Concurrent Symposia 3 and 4
Symposium 3: Emerging Technologies at the Interface of Mechanistic PK and AI
Co-Chairs: Fumiyoshi Yamashita, Kyoto University, Kyoto, Japan and Fabio Broccatelli, Altos Labs, San Diego, California, USA
AI-based Feature Generation for Molecular Design
Tadahaya Mizuno, University of Tokyo, Tokyo, Japan
Mechanistic Multiple Parameter Optimization in Drug Discovery
Fabio Broccatelli, Altos Labs, San Diego, California, USA
Driving Compound Optimization in Early Discovery by Implementing Mechanistic Pharmacokinetic and Machine Learning Models
Wenyi Wang, Genentech, Foster City, California, USA
Computer Aided MetID for Small Molecules and Peptide Drugs
Ismael Zamora, Mass Analytica SL, Sant Cugat del Vallés, Spain
Symposium 4: Recent Advances to Study Drug Transporters
Co-Chairs: Kazuya Maeda, Kitasato University, Tokyo, Japan and Hong Shen, Bristol Myers Squibb, Princeton, New Jersey, USA
Membrane Transporters in Drug Development and as Determinants of Precision Medicine; An Update from the International Transporter Consortium
Kim Brouwer, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA
Discovery, Validation, and Application of Transporter Endogenous Biomarkers: A Work of Translation at BMS
Hong Shen, Bristol Myers Squibb, Belle Mead, New Jersey, USA
Food-derived Neurotrophic Amino Acid Ergothioneine and its Transporter SLC22A4: From Bench to Healthy Food
Yukio Kato, Kanazawa University, Kanazawa, Japan
Role of Intracellular SLC46A3 in the Cytosolic Exposure and Pharmacological Effect of the Payload of Trastuzumab Emtansine (ADC)
Katsuhisa Inoue, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan
5:15 pm - 6:45 pm | 2024 ISSX and JSSX Awards
ISSX Fellowship for Minority Scientists within the North American Region Award Presentation and Lecture
To be presented to Jose Catala Torres, Johns Hopkins University, Baltimore, Maryland, USA
Lecture Title: Determining the Role of Acetylated Microtubules in Double-Strand Break Repair and Mobility
JSSX Award (The Japanese Society for the Study of Xenobiotics Award)
To be presented to Miki Nakajima, Division of Drug Metabolism and Toxicology, WPI Nano Life Science Institute/Faculty of Pharmaceutical Sciences, Kanazawa University
Lecture Title: Unraveling post-transcriptional regulation of drug-metabolizing enzymes and foundational drug metabolism research for drug development and pharmacotherapy
JSSX Kitagawa Memorial Award for Dedication to Drug Discovery
To be presented to Nobuaki Watanabe, Ph.D., Daiichi Sankyo Co., Ltd.
Lecture Title: 30 Years Journey in ADME-PK Research: From Transporters to Quantitative Distribution
2023 JSSX DMPK Award
1st place
Tatsuya Inui, Tomoki Yamashita, Junya Tomita, Jumpei Yokota, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
Title: Comparison of Human Biopsy-derived and Human iPS Cell-derived Intestinal Organoids Established from a Single Individual
2nd place
Akinori Takemura, Sanae Ishii, Yugo Ikeyama, Katsuhiro Esashika, Jun Takahashi, Kousei Ito
Title: New in vitro Screening System to Detect Drug-induced Liver Injury Using a Culture Plate with Low Drug Sorption and High Oxygen Permeability
3rd place
Sotaro Naoi, Mizuki Yamane, Takayuki Nemoto, Motohiro Kato, Ryoichi Saito, Tatsuhiko Tachibana
Title: Physiologically Based Pharmacokinetic (PBPK) Model that Describes Enhanced FcRn-dependent Distribution of Monoclonal Antibodies (mAbs) by PI-engineering in Mice
JSSX Fellows
Kouichi Yoshinari, Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Takafumi Komori, Ph.D., Biopharmaceutical Assessment Unit, Eisai Co., Ltd.
Hiroshi Mizuuchi, Ph.D., Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University
