Meeting Program
Theme: Back to the Future: DMPK Foundations and New Concepts
The 27th North American ISSX Meeting, Back to the Future: DMPK Foundations and New Concepts, will examine how core DMPK principles continue to inform—and evolve alongside—emerging scientific approaches in drug discovery and development.
The scientific program spans artificial intelligence and machine learning in ADME research, advances in drug–drug interaction assessment, mechanistic and systems pharmacology modeling, and real-world case studies highlighting unexpected biotransformations. Additional sessions explore innovative strategies for treating neurodegenerative diseases, pharmacogenetic drivers of drug toxicity, long-acting medicines, structure-based ADME, and the evolving landscape of obesity therapeutics.
Complementing the symposia, in-depth short courses will address microphysiological systems, in vitro–in vivo extrapolation, DMPK characterization of biologics, and emerging insights into extrahepatic metabolism, offering attendees both foundational knowledge and forward-looking perspectives on the future of DMPK.
Day One: Sunday, October 11
Concurrent Short Courses 1 and 2
Short Course 1 - Opportunities for microphysiological systems in ADME research
Short Course 2 - The A to Z of In Vitro to In Vivo Extrapolation for ADME processes
Concurrent Short Courses 3 & 4
Short Course 3 - (Pre)clinical DMPK characterization of therapeutic antibodies
Short Course 4 - Beyond the liver - exploring the frontiers of extrahepatic metabolism in drug disposition
Day Two: Monday, October 12
Concurrent Symposia 1 & 2
Symposium 1 - Revolutionizing ADME research: Can artificial intelligence and machine learning lead the way?
Symposium 2 - Latest advances in assessment of drug-drug interactions
Concurrent Symposia 3 & 4
Symposium 3 - Mechanistic modeling: from in vitro to systems pharmacology
Symposium 4 - Unanticipated and unique biotransformations - case studies
Day Three: Tuesday, October 13
Concurrent Symposia 5 & 6
Symposium 5 - Breaking barriers: Innovative strategies to treat Alzheimer’s and other neurodegenerative diseases by conquering the blood-brain barrier
Symposium 6 - Pharmacogenetic and clinical factors influencing drug toxicity
Day Four: Wednesday, October 14
Concurrent Symposia 7 & 8
Symposium 7 - Discovery and development of long acting medicines
Symposium 8 - Enabling drug discovery with structure-based and structure-activity ADME
Symposia 9
Symposium 9 - Obesity Treatment: Lessons from the Past, Progress Today, and Promises Ahead